The ICD-10-CM 2021 code set will be sunset January 1, 2022.

The 2022 ICD-10-CM Codes are pushed live on October 1, 2021.

  • 159 codes were added
  • 32 codes were deleted
  • 20 codes were revised

Here is a list of all of the codes that were altered:

ActionICD10 CodeCode description
AddedA7982Anaplasmosis [A. phagocytophilum]
AddedC563Malignant neoplasm of bilateral ovaries
AddedC7963Secondary malignant neoplasm of bilateral ovaries
AddedC847AAnaplastic large cell lymphoma, ALK negative, breast
DeletedD552Anemia due to disorders of glycolytic enzymes
AddedD5521Anemia due to pyruvate kinase deficiency
AddedD5529Anemia due to other disorders of glycolytic enzymes
AddedD75838Other thrombocytosis
AddedD75839Thrombocytosis, unspecified
AddedD8944Hereditary alpha tryptasemia
AddedE75244Niemann-Pick disease type A/N
AddedF32ADepression, unspecified
DeletedF78Other intellectual disabilities
AddedF78A1SYNGAP1-related intellectual disability
AddedF78A9Other genetic related intellectual disability
AddedG0482Acute flaccid myelitis
AddedG4486Cervicogenic headache
Revise fromG7120Congenital myopathy unspecifed
Revise toG7120Congenital myopathy unspecified
DeleteG92Toxic encephalopathy
AddedG9200Immune effector cell-associated neurotoxicity syndrome, grade unspecified
AddedG9201Immune effector cell-associated neurotoxicity syndrome, grade 1
AddedG9202Immune effector cell-associated neurotoxicity syndrome, grade 2
AddedG9203Immune effector cell-associated neurotoxicity syndrome, grade 3
AddedG9204Immune effector cell-associated neurotoxicity syndrome, grade 4
AddedG9205Immune effector cell-associated neurotoxicity syndrome, grade 5
AddedG928Other toxic encephalopathy
AddedG929Unspecified toxic encephalopathy
AddedI5ANon-ischemic myocardial injury (non-traumatic)
DeletedK228Other specified diseases of esophagus
AddedK2281Esophageal polyp
AddedK2282Esophagogastric junction polyp
AddedK2289Other specified disease of esophagus
AddedK31A0Gastric intestinal metaplasia, unspecified
AddedK31A11Gastric intestinal metaplasia without dysplasia, involving the antrum
AddedK31A12Gastric intestinal metaplasia without dysplasia, involving the body (corpus)
AddedK31A13Gastric intestinal metaplasia without dysplasia, involving the fundus
AddedK31A14Gastric intestinal metaplasia without dysplasia, involving cardia
AddedK31A15Gastric intestinal metaplasia without dysplasia, involving multiple sites
AddedK31A19Gastric intestinal metaplasia without dysplasia, unspecified site
AddedK31A21Gastric intestinal metaplasia with low grade dysplasia
AddedK31A22Gastric intestinal metaplasia with high grade dysplasia
AddedK31A29Gastric intestinal metaplasia with dysplasia, unspecified
AddedL24A0Irritant contact dermatitis due to friction or  contact with body fluids, unspecified
AddedL24A1Irritant contact dermatitis due to saliva
AddedL24A2Irritant contact dermatitis due to fecal, urinary or dual incontinence
AddedL24A9Irritant contact dermatitis related to friction or contact with other specified body fluids
AddedL24B0Irritant contact dermatitis related to unspecified stoma or fistula
AddedL24B1Irritant contact dermatitis related to digestive stoma or fistula
AddedL24B2Irritant contact dermatitis related to respiratory stoma or fistula
AddedL24B3Irritant contact dermatitis related to fecal or urinary stoma or fistula
DeletedM311Thrombotic microangiopathy
AddedM3110Thrombotic microangiopathy, unspecified
AddedM3111Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]
AddedM3119Other thrombotic microangiopathy
Revised fromM3500Sicca syndrome, unspecified
Revised toM3500Sjogren syndrome, unspecified
Revised fromM3501Sicca syndrome with keratoconjunctivitis
Revised toM3501Sjogren syndrome with keratoconjunctivitis
Revised fromM3502Sicca syndrome with lung involvement
Revised toM3502Sjogren syndrome with lung involvement
Revised fromM3503Sicca syndrome with myopathy
Revised toM3503Sjogren syndrome with myopathy
Revised fromM3504Sicca syndrome with tubulo-interstitial nephropathy
Revised toM3504Sjogren syndrome with tubulo-interstitial nephropathy
AddedM3505Sjogren syndrome with inflammatory arthritis
AddedM3506Sjogren syndrome with peripheral nervous system involvement
AddedM3507Sjogren syndrome with central nervous system involvement
AddedM3508Sjogren syndrome with gastrointestinal involvement
Revised fromM3509Sicca syndrome with other organ involvement
Revised to M3509Sjogren syndrome with other organ involvement
AddedM350ASjogren syndrome with glomerular disease
AddedM350BSjogren syndrome with vasculitis
AddedM350CSjogren syndrome with dental involvement
AddedM45A0Non-radiographic axial spondyloarthritis of unspecified sites in spine
AddedM45A1
Non-radiographic axial spondyloarthritis of occipito-atlanto-axial region
AddedM45A2Non-radiographic axial spondyloarthritis of cervical region
AddedM45A3Non-radiographic axial spondyloarthritis of cervicothoracic region
AddedM45A4Non-radiographic axial spondyloarthritis of thoracic region
AddedM45A5Non-radiographic axial spondyloarthritis of thoracolumbar region
AddedM45A6Non-radiographic axial spondyloarthritis of lumbar region
AddedM45A7Non-radiographic axial spondyloarthritis of lumosacral region
AddedM45A8Non-radiographic axial spondyloarthritis of sacral and sacrococcygeal region
AddedM45ABNon-radiographic axial spondyloarthritis of multiple sites in spine
DeletedM545Low back pain
AddedM5450Low back pain, unspecified
AddedM5451Vertebrogenic low back pain
AddedM5459Other low back pain
AddedP0082Newborn affected by (positive) maternal group B streptococcus (GBS) colonization
DeletedP09Abnormal findings on neonatal screening
AddedP091Abnormal findings on neonatal screening for inborn errors of metabolism
AddedP092Abnormal findings on neonatal screening for congenital endocrine disease
AddedP093Abnormal findings on neonatal screening for congenital hematologic disorders
AddedP094Abnormal findings on neonatal screening for cystic fibrosis
AddedP095Abnormal findings on neonatal screening for critical congenital heart disease
AddedP096Abnormal findings on neonatal screening for neonatal hearing loss
AddedP098Other abnormal findings on neonatal screening
AddedP099Abnormal findings on neonatal screening, unspecified
DeletedR05Cough
AddedR051Acute cough
AddedR052Subacute cough
AddedR053Chronic cough
AddedR054Cough syncope
AddedR058Other specified cough
AddedR059Cough, unspecified
DeletedR358Other polyuria
AddedR3581Nocturnal polyuria
AddedR3589Other polyuria
AddedR4588Nonsuicidal self-harm
DeletedR633Feeding difficulties
AddedR6330Feeding difficulties, unspecified
AddedR6331Pediatric feeding disorder, acute
AddedR6332Pediatric feeding disorder, chronic
AddedR6339Other feeding difficulties
AddedR7983Abnormal findings of blood amino-acid level
AddedS06A0XATraumatic brain compression without herniation, initial encounter 
AddedS06A0XDTraumatic brain compression without herniation, subsequent encounter
AddedS06A0XSTraumatic brain compression without herniation, sequela
AddedS06A1XATraumatic brain compression with herniation, initial encounter
AddedS06A1XDTraumatic brain compression with herniation, subsequent encounter
AddedS06A1XSTraumatic brain compression with herniation, sequela
AddedT40711APoisoning by cannabis accidental (unintentional), initial encounter
AddedT40711DPoisoning by cannabis, accidental (unintentional), subsequent encounter
AddedT40711SPoisoning by cannabis, accidental (unintentional), sequela
AddedT40712APoisoning by cannabis, intentional self-harm, initial encounter
Added
T40712DPoisoning by cannabis, intentional self-harm,  subsequent encounter
Added
T40712SPoisoning by cannabis, intentional self-harm,  sequela
Added
T40713APoisoning by cannabis, assault, initial encounter
Added
T40713DPoisoning by cannabis, assault, subsequent encounter
Added
T40713SPoisoning by cannabis, assault, sequela
Added
T40714APoisoning by cannabis, undetermined, initial encounter
Added
T40714DPoisoning by cannabis, undetermined, subsequent encounter
Added
T40714SPoisoning by cannabis, undetermined, sequela
Added
T40715AAdverse effect of cannabis, initial encounter
Added
T40715DAdverse effect of cannabis, subsequent encounter
Added
T40715SAdverse effect of cannabis, sequela
AddedT40716AUnderdosing of cannabis, initial encounter
AddedT40716DUnderdosing of cannabis, subsequent encounter
AddedT40716SUnderdosing of cannabis, sequela
AddedT40721APoisoning by synthetic cannabinoids, accidental (unintentional), initial encounter
AddedT40721DPoisoning by synthetic cannabinoids, accidental (unintentional), subsequent encounter
AddedT40721SPoisoning by synthetic cannabinoids, accidental (unintentional), sequela
AddedT40722APoisoning by synthetic cannabinoids, intentional self-harm, initial encounter
AddedT40722DPoisoning by synthetic cannabinoids, intentional self-harm, subsequent encounter
AddedT40722SPoisoning by synthetic cannabinoids, intentional self-harm sequela
AddedT40723APoisoning by synthetic cannabinoids, assault, initial encounter
AddedT40723DPoisoning by synthetic cannabinoids, assault, subsequent encounter
AddedT40723SPoisoning by synthetic cannabinoids, assault, sequela
AddedT40724APoisoning by synthetic cannabinoids, undetermined, initial encounter
AddedT40724DPoisoning by synthetic cannabinoids, undetermined, subsequent encounter
AddedT40724SPoisoning by synthetic cannabinoids, undetermined, sequela
AddedT40725AAdverse effect of synthetic cannabinoids, initial encounter
AddedT40725DAdverse effect of synthetic cannabinoids, subsequent encounter
AddedT40725SAdverse effect of synthetic cannabinoids, sequela
AddedT40726AUnderdosing of synthetic cannabinoids, initial encounter
AddedT40726DUnderdosing of synthetic cannabinoids, subsequent encounter
AddedT40726SUnderdosing of synthetic cannabinoids, sequela
Deleted
T407X1APoisoning by cannabis (derivatives), accidental (unintentional), initial encounter
Deleted
T407X1DPoisoning by cannabis (derivatives), accidental (unintentional), subsequent encounter
Deleted
T407X1SPoisoning by cannabis (derivatives), accidental (unintentional), sequela
DeletedT407X2APoisoning by cannabis (derivatives), intentional self-harm, initial encounter
DeletedT407X2DPoisoning by cannabis (derivatives), intentional self-harm, subsequent encounter
DeletedT407X2SPoisoning by cannabis (derivatives), intentional self-harm, sequela
DeletedT407X3APoisoning by cannabis (derivatives), assault, initial encounter
DeletedT407X3DPoisoning by cannabis (derivatives), assault, subsequent encounter
DeletedT407X3SPoisoning by cannabis (derivatives), assault, sequela
DeletedT407X4APoisoning by cannabis (derivatives), undetermined, initial encounter
DeletedT407X4DPoisoning by cannabis (derivatives), undetermined, subsequent encounter
DeletedT407X4SPoisoning by cannabis (derivatives), undetermined, sequela
DeletedT407X5AAdverse effect of cannabis (derivatives), initial encounter
DeletedT407X5DAdverse effect of cannabis (derivatives), subsequent encounter
DeletedT407X5SAdverse effect of cannabis (derivatives), sequela
DeletedT407X6AUnderdosing of cannabis (derivatives), initial encounter
DeletedT407X6DUnderdosing of cannabis (derivatives), subsequent encounter
DeletedT407X6SUnderdosing of cannabis (derivatives), sequela
Revised fromT63611AToxic effect of contact with Portugese Man-o-war, accidental (unintentional), initial encounter
Revised toT63611AToxic effect of contact with Portuguese Man-o-war, accidental (unintentional), initial encounter
Revised from
T63611DToxic effect of contact with Portugese Man-o-war, accidental (unintentional), subsequent encounter
Revised toT63611DToxic effect of contact with Portuguese Man-o-war, accidental (unintentional), subsequent encounter
Revised fromT63611SToxic effect of contact with Portugese Man-o-war, accidental (unintentional), sequela
Revised toT63611SToxic effect of contact with Portuguese Man-o-war, accidental (unintentional), sequela
Revised fromT63612AToxic effect of contact with Portugese Man-o-war, intentional self-harm, initial encounter
Revised toT63612AToxic effect of contact with Portuguese Man-o-war, intentional self-harm, initial encounter
Revised fromT63612DToxic effect of contact with Portugese Man-o-war, intentional self-harm, subsequent encounter
Revised toT63612DToxic effect of contact with Portuguese Man-o-war, intentional self-harm, subsequent encounter
Revised fromT63612SToxic effect of contact with Portugese Man-o-war, intentional self-harm, subsequent encounter
Revised toT63612SToxic effect of contact with Portuguese Man-o-war, intentional self-harm, subsequent encounter
Revised fromT63613AToxic effect of contact with Portugese Man-o-war, assault, initial encounter
Revised toT63613AToxic effect of contact with Portuguese Man-o-war, assault, initial encounter
Revised fromT63613DToxic effect of contact with Portugese Man-o-war, assault, subsequent encounter
Revised toT63613DToxic effect of contact with Portuguese Man-o-war, assault, subsequent encounter
Revised fromT63613SToxic effect of contact with Portugese Man-o-war, assault, sequela
Revised toT63613SToxic effect of contact with Portuguese Man-o-war, assault, sequela
Revised fromT63614AToxic effect of contact with Portugese Man-o-war, undetermined, initial encounter
Revised to
T63614AToxic effect of contact with Portuguese Man-o-war, undetermined, initial encounter
Revised fromT63614DToxic effect of contact with Portugese Man-o-war, undetermined, subsequent encounter
Revised toT63614DToxic effect of contact with Portuguese Man-o-war, undetermined, subsequent encounter
Revised fromT63614SToxic effect of contact with Portugese Man-o-war, undetermined, sequela
Revised toT63614SToxic effect of contact with Portuguese Man-o-war, undetermined, sequela
AddedT8082XAComplication of immune effector cellular therapy, initial encounter
AddedT8082XDComplication of immune effector cellular therapy, subsequent encounter
AddedT8082XSComplication of immune effector cellular therapy, sequela
AddedU099Post COVID-19 condition unspecified
AddedY35899ALegal intervention involving other specified means, unspecified person injured, initial encounter
AddedY35899DLegal intervention involving other specified means, unspecified person injured, subsequent encounter
AddedY35899SLegal intervention involving other specified means, unspecified person injured sequela
AddedZ555Less than a high school diploma
Added
Z586Inadequate drinking-water supply
DeletedZ590Homelessness
Added
Z5900Homelessness unspecified
AddedZ5901Sheltered homelessness
AddedZ5902Unsheltered homelessness
DeletedZ594Lack of adequate food and safe drinking water
AddedZ5941Food insecurity
AddedZ5948Other specified lack of adequate food
DeletedZ598Other problems related to housing and economic circumstances
AddedZ59811Housing instability, housed, with risk of homelessness
AddedZ59812Housing instability, housed, homelessness in past 12 months
AddedZ59819Housing instability, housed unspecified
AddedZ5989Other problems related to housing and economic circumstances
AddedZ7185Encounter for immunization safety counseling
AddedZ91014Allergy to mammalian meats
DeletedZ915Personal history of self-harm
AddedZ9151Personal history of suicidal behavior
AddedZ9152Personal history of nonsuicidal self-harm
Revised fromZ9225
Personal history of immunosupression therapy
Revised toZ9225Personal history of immunosuppression therapy
AddedZ92850Personal history of Chimeric Antigen Receptor T-cell therapy
AddedZ92858Personal history of other cellular therapy
AddedZ92859Personal history of cellular therapy, unspecified
AddedZ9286Personal history of gene therapy



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